As of November 2019, more than half of global large-scale CCS facilities are in the USA, thanks to a history of sustained government support for the technologies. Recently, the USA has seen a raft of new developments on the policy and project side signaling a reinvigorated push to commercialize the technology. Analyzing these recent developments using a policy-priorities framework for CCS commercialization developed by the Global CCS Institute, the paper assesses the USA’s position to lead large-scale deployment of CCS technologies to commercialization. The paper seeks to provide an overview of CCS deployment in the USA while assessing the maturity of the US deployment framework, including policies and infrastructure. It concludes that the USA is in a prime position due to the political economic characteristics of its energy economy, resource wealth and innovation-driven manufacturing sector.